Article
Fast identification of biological pathways associated with a quantitative trait using group lasso with overlaps.
Statistical applications in genetics and molecular biology - 6 Jan 2012
Silver Matt, Montana Giovanni
Abstract excerpt
Where causal SNPs (single nucleotide polymorphisms) tend to accumulate within biological pathways, the incorporation of prior pathways information into a statistical model is expected to increase the power to detect true associations in a genetic association study. Most existing pathways-based methods rely on marginal SNP statistics and do not fully exploit the dependence patterns among SNPs within pathways.We...
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