Analysing biological pathways in genome-wide association studies.

Abstract excerpt

Genome-wide association (GWA) studies have typically focused on the analysis of single markers, which often lacks the power to uncover the relatively small effect sizes conferred by most genetic variants. Recently, pathway-based approaches have been developed, which use prior biological knowledge on gene function to facilitate more powerful analysis of GWA study data sets. These approaches typically examine...

Topics

• Animals
• Crohn Disease
• Genetic Predisposition to Disease
• Genome-Wide Association Study
• Humans
• Interleukin-12
• Interleukin-23
• Polymorphism, Single Nucleotide
• Signal Transduction