Article
Pathway-based approach using hierarchical components of rare variants to analyze multiple phenotypes.
BMC bioinformatics - 8 May 2018
Lee Sungyoung, Kim Yongkang, Choi Sungkyoung, Hwang Heungsun, Park Taesung
Abstract excerpt
BACKGROUND: As one possible solution to the "missing heritability" problem, many methods have been proposed that apply pathway-based analyses, using rare variants that are detected by next generation sequencing technology. However, while a number of methods for pathway-based rare-variant analysis of multiple phenotypes have been proposed, no method considers a unified model that incorporate multiple pathways....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.