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Article

Enzyme overexpression - an exercise toward understanding regulation of heparan sulfate biosynthesis.

Scientific reports - 11 Aug 2016

Fang Jianping, Song Tianyi, Lindahl Ulf, Li Jin-Ping

Abstract excerpt

Biosynthesis of heparan sulfate (HS) involves conversion of D-glucuronic acid (GlcA) to L-iduronic acid (IdoA) units catalyzed by glucuronyl C5-epimerase (Hsepi). IdoA units are the favored substrate for 2-O-sulfotransferase (2OST). We used HEK293 cells as a model to investigate the effects of overexpression of these enzymes on HS structure. Overexpression of Hsepi alone resulted in an unexpected increase in HS...

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Identifiers

PMID: 27511124
DOI: 10.1038/srep31242
PMCID: PMC4980632

Genes

EBP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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