Accumulation of a pentasaccharide terminating in alpha-N-acetylglucosamine in an animal cell mutant defective in heparan sulfate biosynthesis.

doi:10.1074/jbc.270.21.12557

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Accumulation of a pentasaccharide terminating in alpha-N-acetylglucosamine in an animal cell mutant defective in heparan sulfate biosynthesis.

The Journal of biological chemistry - 26 May 1995

Zhang L, Esko J D

Abstract excerpt

Heparan sulfate biosynthesis initiates by the transfer of alpha-D-GlcNAc from UDP-GlcNAc to the D-GlcA moiety of the linkage tetrasaccharide, GlcA beta 1-3Gal beta 1-3Gal beta 1-4Xyl beta 1-core protein. The enzyme catalyzing this reaction differs from the alpha-GlcNAc transferase involved in cha...

Topics

Acetylglucosamine
Amino Acid Sequence
Animals
CHO Cells
Carbohydrate Sequence
Cricetinae
Glycosaminoglycans
Heparin Lyase
Heparitin Sulfate
Molecular Sequence Data
Mutation
Oligosaccharides
Polysaccharide-Lyases
Proteoglycans
Receptors, Transforming Growth Factor beta
Recombinant Fusion Proteins

Source

Open in PubMed

Identifiers

PMID: 7759502
DOI: 10.1074/jbc.270.21.12557

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7759502-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics