Article
The melanocortin-1 receptor gene polymorphism and association with human skin cancer.
Progress in molecular biology and translational science - 1 Jan 2009
Beaumont Kimberley A, Liu Yan Yan, Sturm Richard A
Abstract excerpt
The melanocortin-1 receptor (MC1R) is a key gene involved in the regulation of melanin synthesis and encodes a G-protein coupled receptor expressed on the surface of the melanocyte in the skin and hair follicles. MC1R activation after ultraviolet radiation exposure results in the production of the dark eumelanin pigment and the tanning process in humans, providing physical protection against DNA damage. The MC1R...
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