Article
Defining the quantitative contribution of the melanocortin 1 receptor (MC1R) to variation in pigmentary phenotype.
Annals of the New York Academy of Sciences - 1 Jun 2003
Ha T, Naysmith L, Waterston K, Oh C, Weller R, Rees J L
Abstract excerpt
The melanocortin 1 receptor (MC1R) is a key determinant of pigmentary phenotype. Several sequence variants of the MC1R have been described, many of which are associated with red hair and cutaneous sensitivity to ultraviolet radiation even in the absence of red hair. Red hair approximates to an autosomal recessive trait, and most people with red hair are compound heterozygote or homozygous for limited numbers of...
Topics
- Animals
- Humans
- Melanins
- Phenotype
- Pigmentation
- Receptors, Corticotropin
- Receptors, Melanocortin
- Skin
- Ultraviolet Rays