Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MC1R, the cAMP pathway, and the response to solar UV: extending the horizon beyond pigmentation.

Pigment cell & melanoma research - 1 Sept 2014

García-Borrón Jose C, Abdel-Malek Zalfa, Jiménez-Cervantes Celia

Abstract excerpt

The melanocortin 1 receptor (MC1R) is a G protein-coupled receptor crucial for the regulation of melanocyte proliferation and function. Upon binding melanocortins, MC1R activates several signaling cascades, notably the cAMP pathway leading to synthesis of photoprotective eumelanin. Polymorphisms in the MC1R gene are a major source of normal variation of human hair color and skin pigmentation, response to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cyclic AMP
Share to Melanocytes
Share to Neoplasms, Radiation-Induced

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Pigmentation

Share to Protein Processing, Post-Translational

Share to Receptor, Melanocortin, Type 1

Share to Skin Pigmentation

Share to Ultraviolet Rays

Source

Open in PubMed Open full text

Identifiers

PMID: 24807163
DOI: 10.1111/pcmr.12257
PMCID: PMC4150834

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MC1R, the cAMP pathway, and the response to solar UV: extending the horizon beyond pigmentation.PMID 24807163Read ↗

MC1R and the response of melanocytes to ultraviolet radiation.Semantic proximity Read ↗

The α‐melanocyte‐stimulating hormone/melanocortin‐1 receptor interaction: A driver of pleiotropic effects beyond pigmentationSemantic proximity Read ↗

The melanocortin-1 receptor gene polymorphism and association with human skin cancer.Semantic proximity Read ↗

Melanocortin-1 receptor (MC1R): a review for dermatologists.Semantic proximity Read ↗

MC1R Functions, Expression, and Implications for Targeted Therapy.Semantic proximity Read ↗

Melanocortin 1 receptor variants: functional role and pigmentary associations.Semantic proximity Read ↗

The Genetics of Sun Sensitivity in HumansSemantic proximity Read ↗

Participation of the melanocortin-1 receptor in the UV control of pigmentation.Semantic proximity Read ↗

The Melanocortin 1 Receptor and the UV Response of Human Melanocytes—A Shift in Paradigm<sup>†</sup>Semantic proximity Read ↗

Variants of the melanocortin-1 receptor: do they matter clinically?Semantic proximity Read ↗

An overview of benefits and risks of chronic melanocortin‐1 receptor activationSemantic proximity Read ↗

MC1R: Front and Center in the Bright Side of Dark Eumelanin and DNA RepairSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.