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Article

The Genetics of Sun Sensitivity in Humans

4 Oct 2004

Abstract excerpt

Humans vary >100-fold in their sensitivity to the harmful effects of ultraviolet radiation. The main determinants of sensitivity are melanin pigmentation and less-well-characterized differences in skin inflammation and repair processes. Pigmentation has a high heritability, but susceptibility to cancers of the skin, a key marker of sun sensitivity, is less heritable. Despite a large number of murine coat-color...

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PMID: 15372380
DOI: 10.1086/425285

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