Article
Melanocortin MC₁ receptor in human genetics and model systems.
European journal of pharmacology - 11 Jun 2011
Beaumont Kimberley A, Wong Shu S, Ainger Stephen A, Liu Yan Yan, Patel Mira P, Millhauser Glenn L, Smith Jennifer J, Alewood Paul F, Leonard J Helen, Sturm Richard A
Abstract excerpt
The melanocortin MC(1) receptor is a G-protein coupled receptor expressed in the melanocytes of the skin and hair and is known for its key role in the regulation of human pigmentation. Melanocortin MC(1) receptor activation after ultraviolet radiation exposure results in a switch from the red/yellow pheomelanin to the brown/black eumelanin pigment synthesis within cutaneous melanocytes; this pigment is then...
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