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Article

The Hippo pathway regulates the bantam microRNA to control cell proliferation and apoptosis in Drosophila.

Cell - 25 Aug 2006

Thompson Barry J, Cohen Stephen M

Abstract excerpt

The Hippo signaling pathway acts upon the Yorkie transcriptional activator to control tissue growth in Drosophila. Activated Yorkie drives growth by stimulating cell proliferation and inhibiting apoptosis, but how it achieves this is not understood. Yorkie is known to activate Cyclin E (CycE) and the apoptosis inhibitor DIAP1. However, overexpression of these targets is not sufficient to cause tissue overgrowth....

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Identifiers

PMID: 16923395
DOI: 10.1016/j.cell.2006.07.013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

The Hippo pathway regulates the bantam microRNA to control cell proliferation and apoptosis in Drosophila.PMID 16923395Read ↗

The bantam microRNA is a target of the hippo tumor-suppressor pathway.Semantic proximity Read ↗

bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in Drosophila.Semantic proximity Read ↗

hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts.Semantic proximity Read ↗

The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP.Semantic proximity Read ↗

A screen for conditional growth suppressor genes identifies the Drosophila homolog of HD-PTP as a regulator of the oncoprotein Yorkie.Semantic proximity Read ↗

The role of the Hippo pathway in human disease and tumorigenesisSemantic proximity Read ↗

The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis.Semantic proximity Read ↗

Dmp53 activates the Hippo pathway to promote cell death in response to DNA damage.Semantic proximity Read ↗

salvador Promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines.Semantic proximity Read ↗

The WW domain protein Kibra acts upstream of Hippo in Drosophila.Semantic proximity Read ↗

The bantam gene regulates Drosophila growth.Semantic proximity Read ↗

Akt is negatively regulated by Hippo signaling for growth inhibition in Drosophila.Semantic proximity Read ↗

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