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Article

Kibra is a regulator of the Salvador/Warts/Hippo signaling network.

Developmental cell - 16 Feb 2010

Genevet Alice, Wehr Michael C, Brain Ruth, Thompson Barry J, Tapon Nicolas

Abstract excerpt

The Salvador (Sav)/Warts (Wts)/Hippo (Hpo) (SWH) network controls tissue growth by inhibiting cell proliferation and promoting apoptosis. The core of the pathway consists of a MST and LATS family kinase cascade that ultimately phosphorylates and inactivates the YAP/Yorkie (Yki) transcription coac...

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Identifiers

PMID: 20159599
DOI: 10.1016/j.devcel.2009.12.011
PMCID: PMC2845807

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20159599-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Kibra is a regulator of the Salvador/Warts/Hippo signaling network.PMID 20159599Read ↗

The WW domain protein Kibra acts upstream of Hippo in Drosophila.Semantic proximity Read ↗

The Drosophila RASSF homolog antagonizes the hippo pathway.Semantic proximity Read ↗

hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts.Semantic proximity Read ↗

Crumbs regulates Salvador/Warts/Hippo signaling in Drosophila via the FERM-domain protein Expanded.Semantic proximity Read ↗

Crumbs promotes expanded recognition and degradation by the SCF(Slimb/β-TrCP) ubiquitin ligase.Semantic proximity Read ↗

The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis.Semantic proximity Read ↗

Lgl/aPKC and Crb regulate the Salvador/Warts/Hippo pathway.Semantic proximity Read ↗

The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP.Semantic proximity Read ↗

The role of the Hippo pathway in human disease and tumorigenesisSemantic proximity Read ↗

The apical transmembrane protein Crumbs functions as a tumor suppressor that regulates Hippo signaling by binding to Expanded.Semantic proximity Read ↗

The Hippo Pathway Targets Rae1 to Regulate Mitosis and Organ Size and to Feed Back to Regulate Upstream Components Merlin, Hippo, and Warts.Semantic proximity Read ↗

Implications for precision medicine and the reciprocal control of microRNAs by Hippo and TAZ signaling in breast cancerSemantic proximity Read ↗

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