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Article

Crumbs promotes expanded recognition and degradation by the SCF(Slimb/β-TrCP) ubiquitin ligase.

Proceedings of the National Academy of Sciences of the United States of America - 13 May 2014

Ribeiro Paulo, Holder Maxine, Frith David, Snijders Ambrosius P, Tapon Nicolas

Abstract excerpt

In epithelial tissues, growth control depends on the maintenance of proper architecture through apicobasal polarity and cell-cell contacts. The Hippo signaling pathway has been proposed to sense tissue architecture and cell density via an intimate coupling with the polarity and cell contact machineries. The apical polarity protein Crumbs (Crb) controls the activity of Yorkie (Yki)/Yes-activated protein, the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Epithelial Cells

Share to SKP Cullin F-Box Protein Ligases

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Source

Open in PubMed Open full text

Identifiers

PMID: 24778256
DOI: 10.1073/pnas.1315508111
PMCID: PMC4024906

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Crumbs promotes expanded recognition and degradation by the SCF(Slimb/β-TrCP) ubiquitin ligase.PMID 24778256Read ↗

Crumbs regulates Salvador/Warts/Hippo signaling in Drosophila via the FERM-domain protein Expanded.Semantic proximity Read ↗

The apical transmembrane protein Crumbs functions as a tumor suppressor that regulates Hippo signaling by binding to Expanded.Semantic proximity Read ↗

Kibra is a regulator of the Salvador/Warts/Hippo signaling network.Semantic proximity Read ↗

Lgl/aPKC and Crb regulate the Salvador/Warts/Hippo pathway.Semantic proximity Read ↗

Mosaic Eyes is a novel component of the Crumbs complex and negatively regulates photoreceptor apical size.Semantic proximity Read ↗

Crumbs, the Drosophila homologue of human CRB1/RP12, is essential for photoreceptor morphogenesis.Semantic proximity Read ↗

Lgl, aPKC, and Crumbs regulate the Salvador/Warts/Hippo pathway through two distinct mechanisms.Semantic proximity Read ↗

Crumbs controls epithelial integrity by inhibiting Rac1 and PI3K.Semantic proximity Read ↗

Crumbs, Moesin and Yurt regulate junctional stability and dynamics for a proper morphogenesis of the Drosophila pupal wing epithelium.Semantic proximity Read ↗

The cell adhesion molecule echinoid functions as a tumor suppressor and upstream regulator of the Hippo signaling pathway.Semantic proximity Read ↗

Yurt, Coracle, Neurexin IV and the Na(+),K(+)-ATPase form a novel group of epithelial polarity proteins.Semantic proximity Read ↗

Structure of Crumbs tail in complex with the PALS1 PDZ-SH3-GK tandem reveals a highly specific assembly mechanism for the apical Crumbs complex.Semantic proximity Read ↗

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