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Article

Drosophila endocytic neoplastic tumor suppressor genes regulate Sav/Wts/Hpo signaling and the c-Jun N-terminal kinase pathway.

Cell cycle (Georgetown, Tex.) - 1 Dec 2011

Robinson Brian S, Moberg Kenneth H

Abstract excerpt

Genetic screens in the fruit fly Drosophila melanogaster have identified a class of neoplastic tumor suppressor genes (endocytic nTSGs), which encode proteins that localize to endosomes and facilitate the trafficking of membrane-bound receptors and adhesion molecules into the degradative lysosome. Loss of endocytic nTSGs transforms imaginal disc epithelia into highly proliferative, invasive tissues that fail to...

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Identifiers

PMID: 22101275
DOI: 10.4161/cc.10.23.18243
PMCID: PMC3272291

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