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Article

The Hippo pathway regulates apical-domain size independently of its growth-control function.

Journal of cell science - 15 Jul 2009

Genevet Alice, Polesello Cédric, Blight Ken, Robertson Francesca, Collinson Lucy M, Pichaud Franck, Tapon Nicolas

Abstract excerpt

The Hippo pathway, identified in Drosophila and conserved in vertebrates, regulates tissue growth by promoting cell cycle exit and apoptosis. In addition to their well-characterised overproliferation phenotype, adult Drosophila epithelial cells mutant for the kinases Hippo and Warts have hypertrophic apical domains. Here we examine the molecular basis of this apical hypertrophy and its impact on cell...

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Identifiers

PMID: 19531586
DOI: 10.1242/jcs.041806
PMCID: PMC2704876

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The Hippo pathway regulates apical-domain size independently of its growth-control function.PMID 19531586Read ↗

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Hippo signaling pathway and organ size control.Semantic proximity Read ↗

Crumbs regulates Salvador/Warts/Hippo signaling in Drosophila via the FERM-domain protein Expanded.Semantic proximity Read ↗

The apical scaffold big bang binds to spectrins and regulates the growth of Drosophila melanogaster wing discs.Semantic proximity Read ↗

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The Hippo Pathway Targets Rae1 to Regulate Mitosis and Organ Size and to Feed Back to Regulate Upstream Components Merlin, Hippo, and Warts.Semantic proximity Read ↗

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