Article
Phosphaturic action of fibroblast growth factor 23 in Npt2 null mice.
American journal of physiology. Renal physiology - 1 Jun 2010
Tomoe Yuka, Segawa Hiroko, Shiozawa Kazuyo, Kaneko Ichiro, Tominaga Rieko, Hanabusa Etsuyo, Aranami Fumito, Furutani Junya, Kuwahara Shoji, Tatsumi Sawako, Matsumoto Mitsutu, Ito Mikiko, Miyamoto Ken-ichi
Abstract excerpt
In the present study, we evaluated the roles of type II and type III sodium-dependent P(i) cotransporters in fibroblast growth factor 23 (FGF23) activity by administering a vector encoding FGF23 with the R179Q mutation (FGF23M) to wild-type (WT) mice, Npt2a knockout (KO) mice, Npt2c KO mice, and Npt2a(-/-)Npt2c(-/-) mice (DKO mice). In Npt2a KO mice, FGF23M induced severe hypophosphatemia and markedly decreased...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.