Article
Transgenic mice expressing fibroblast growth factor 23 under the control of the alpha1(I) collagen promoter exhibit growth retardation, osteomalacia, and disturbed phosphate homeostasis.
Endocrinology - 1 Jul 2004
Larsson Tobias, Marsell Richard, Schipani Ernestina, Ohlsson Claes, Ljunggren Osten, Tenenhouse Harriet S, Jüppner Harald, Jonsson Kenneth B
Abstract excerpt
Mutations in the fibroblast growth factor 23 gene, FGF23, cause autosomal dominant hypophosphatemic rickets (ADHR). The gene product, FGF-23, is produced by tumors from patients with oncogenic osteomalacia (OOM), circulates at increased levels in most patients with X-linked hypophosphatemia (XLH) and is phosphaturic when injected into rats or mice, suggesting involvement in the regulation of phosphate (Pi)...
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