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Gene expression analysis of kidneys from transgenic mice expressing fibroblast growth factor-23

2 Oct 2007

Abstract excerpt

BACKGROUND: Fibroblast growth factor-23 (FGF23), a circulating protein produced in bone, causes decreased renal inorganic phosphate (Pi) reabsorption by reducing the expression of the sodium phosphate cotransporter type 2a (Npt2a). We have previously generated transgenic mice expressing human wild-type (WT) FGF23 under the control of the alpha1 (I) collagen promoter. METHODS: In this study, we performed a...

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PMID: 17911089
DOI: 10.1093/ndt/gfm672

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