Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Amelioration of the premature ageing-like features of Fgf-23 knockout mice by genetically restoring the systemic actions of FGF-23.

The Journal of pathology - 1 Nov 2008

DeLuca S, Sitara D, Kang K, Marsell R, Jonsson K, Taguchi T, Erben R G, Razzaque M S, Lanske B

Abstract excerpt

Genetic ablation of fibroblast growth factor 23 from mice (Fgf-23(-/-)) results in a short lifespan with numerous abnormal biochemical and morphological features. Such features include kyphosis, hypogonadism and associated infertility, osteopenia, pulmonary emphysema, severe vascular and soft tissue calcifications, and generalized atrophy of various tissues. To determine whether these widespread anomalies in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aging, Premature
Share to Calcitriol

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fibroblast Growth Factor-23

Share to Fibroblast Growth Factors

Share to Hindlimb

Share to Osteoblasts

Share to Parathyroid Hormone

Share to Phosphates

Source

Open in PubMed Open full text

Identifiers

PMID: 18729070
DOI: 10.1002/path.2409
PMCID: PMC2776048

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Amelioration of the premature ageing-like features of Fgf-23 knockout mice by genetically restoring the systemic actions of FGF-23.PMID 18729070Read ↗

Premature aging-like phenotype in fibroblast growth factor 23 null mice is a vitamin D-mediated process.Semantic proximity Read ↗

Genetic evidence of serum phosphate-independent functions of FGF-23 on bone.Semantic proximity Read ↗

Homozygous ablation of fibroblast growth factor-23 results in hyperphosphatemia and impaired skeletogenesis, and reverses hypophosphatemia in Phex-deficient mice.Semantic proximity Read ↗

Transgenic mice expressing fibroblast growth factor 23 under the control of the alpha1(I) collagen promoter exhibit growth retardation, osteomalacia, and disturbed phosphate homeostasis.Semantic proximity Read ↗

In vivo genetic evidence for klotho-dependent, fibroblast growth factor 23 (Fgf23) -mediated regulation of systemic phosphate homeostasis.Semantic proximity Read ↗

Premature aging in klotho mutant mice: cause or consequence?Semantic proximity Read ↗

Overexpression of the DMP1 C-terminal fragment stimulates FGF23 and exacerbates the hypophosphatemic rickets phenotype in Hyp mice.Semantic proximity Read ↗

Hypophosphatemia-mediated hypotension in transgenic mice overexpressing human FGF-23.Semantic proximity Read ↗

FGF23 in skeletal modeling and remodeling.Semantic proximity Read ↗

Compound deletion of Fgfr3 and Fgfr4 partially rescues the Hyp mouse phenotype.Semantic proximity Read ↗

Human fibroblast growth factor-23 mutants suppress Na+-dependent phosphate co-transport activity and 1alpha,25-dihydroxyvitamin D3 production.Semantic proximity Read ↗

A Control Region Near the Fibroblast Growth Factor 23 Gene Mediates Response to Phosphate, 1,25(OH)2D3, and LPS In VivoSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.