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Article

Genetic evidence of serum phosphate-independent functions of FGF-23 on bone.

PLoS genetics - 8 Aug 2008

Sitara Despina, Kim Somi, Razzaque Mohammed S, Bergwitz Clemens, Taguchi Takashi, Schüler Christiane, Erben Reinhold G, Lanske Beate

Abstract excerpt

Maintenance of physiologic phosphate balance is of crucial biological importance, as it is fundamental to cellular function, energy metabolism, and skeletal mineralization. Fibroblast growth factor-23 (FGF-23) is a master regulator of phosphate homeostasis, but the molecular mechanism of such regulation is not yet completely understood. Targeted disruption of the Fgf-23 gene in mice (Fgf-23-/-) elicits...

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PMID: 18688277
DOI: 10.1371/journal.pgen.1000154
PMCID: PMC2483943

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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