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Article

Human fibroblast growth factor-23 mutants suppress Na+-dependent phosphate co-transport activity and 1alpha,25-dihydroxyvitamin D3 production.

The Journal of biological chemistry - 24 Jan 2003

Saito Hitoshi, Kusano Kenichiro, Kinosaki Masahiko, Ito Hirotaka, Hirata Michinori, Segawa Hiroko, Miyamoto Ken-Ichi, Fukushima Naoshi

Abstract excerpt

The human fibroblast growth factor 23 (hFGF23) and its autosomal dominant hypophosphatemic rickets (ADHR) mutant genes were incorporated into animals by naked DNA injection to investigate the action on phosphate homeostasis in vivo. The hFGF23 mutants (R176Q, R179Q, and R179W) markedly reduced serum phosphorus (6.2-6.9 mg/dl) compared with the plasmid MOCK (8.5 mg/dl). However, native hFGF23 did not affect serum...

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Identifiers

PMID: 12419819
DOI: 10.1074/jbc.M207872200

Genes

PTH
FGF23

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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