Article
Na/P(i) cotransporter ( Npt2) gene disruption increases duodenal calcium absorption and expression of epithelial calcium channels 1 and 2.
Pflugers Archiv : European journal of physiology - 1 Aug 2002
Tenenhouse Harriet S, Gauthier Claude, Martel Josée, Hoenderop Joost G J, Hartog Anita, Meyer Martha H, Meyer Ralph A, Bindels René J M
Abstract excerpt
Mice homozygous for the disrupted type-II Na/P(i) cotransporter gene ( Npt2(-/-)) exhibit hypophosphataemia, increased serum concentration of 1,25-dihydroxyvitamin D (1,25-(OH)(2)D) and calcium (Ca) and elevated urinary Ca excretion. To determine whether the hypercalcaemia and hypercalciuria are secondary to 1,25-(OH)(2)D-stimulated intestinal Ca absorption, we examined the effect of Npt2 gene disruption on serum...
Topics
- Animals
- Calbindins
- Calcium
- Calcium Channels
- Duodenum
- Fasting
- Female
- Gene Expression
- Hypophosphatemia
- Intestinal Absorption
- Male
- Mice
- Mice, Knockout
- Mutagenesis