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Article

Tau-tubulin kinase 1 enhances prefibrillar tau aggregation and motor neuron degeneration in P301L FTDP-17 tau-mutant mice.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Aug 2010

Xu Jiqing, Sato Shinji, Okuyama Satoshi, Swan Russell J, Jacobsen Michael T, Strunk Elena, Ikezu Tsuneya

Abstract excerpt

Tau-tubulin kinase-1 (TTBK1) phosphorylates microtubule-associated protein tau at specific serine/threonine residues found in paired helical filaments (PHFs), and its expression is up-regulated in the brain in Alzheimer disease, suggesting its role in tauopathy pathogenesis. To understand the effects of TTBK1 on tauopathy in vivo, we have developed bigenic mice overexpressing full-length TTBK1 and the P301L tau...

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Source

Identifiers

PMID: 20354135
DOI: 10.1096/fj.09-150144

Genes

TTBK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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