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Article

Progressive Motor Deficit is Mediated by the Denervation of Neuromuscular Junctions and Axonal Degeneration in Transgenic Mice Expressing Mutant (P301S) Tau Protein.

Journal of Alzheimer's disease : JAD - 1 Jan 2017

Yin Zhuoran, Valkenburg Femke, Hornix Betty E, Mantingh-Otter Ietje, Zhou Xingdong, Mari Muriel, Reggiori Fulvio, Van Dam Debby, Eggen Bart J L, De Deyn Peter P, Boddeke Erik

Abstract excerpt

Tauopathies include a variety of neurodegenerative diseases associated with the pathological aggregation of hyperphosphorylated tau, resulting in progressive cognitive decline and motor impairment. The underlying mechanism for motor deficits related to tauopathy is not yet fully understood. Here, we use a novel transgenic tau mouse line, Tau 58/4, with enhanced neuron-specific expression of P301S mutant tau to...

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PMID: 28222529
DOI: 10.3233/JAD-161206

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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