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Article

Early-onset cognitive deficits and axonal transport dysfunction in P301S mutant tau transgenic mice.

Neuroscience research - 1 Mar 2014

Onishi Tomohiro, Matsumoto Yoshio, Hattori Masahiko, Obayashi Yuka, Nakamura Kimie, Yano Takashi, Horiguchi Takashi, Iwashita Hiroki

Abstract excerpt

Alzheimer's disease (AD) and frontotemporal lobar degeneration (FTLD) are neurodegenerative "tauopathies" characterized by hyperphosphorylated tau accumulation and neurofibrillary tangles. The P301S mutation of tau, a causal mutation of a familial type of FTLD, is believed to be involved in neurodegenerative progression. We developed a transgenic mouse, named TPR50, harboring human P301S tau. Tau phosphorylation...

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Identifiers

PMID: 24406748
DOI: 10.1016/j.neures.2013.12.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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