Article
Abundant tau filaments and nonapoptotic neurodegeneration in transgenic mice expressing human P301S tau protein.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Nov 2002
Allen Bridget, Ingram Esther, Takao Masaki, Smith Michael J, Jakes Ross, Virdee Kanwar, Yoshida Hirotaka, Holzer Max, Craxton Molly, Emson Piers C, Atzori Cristiana, Migheli Antonio, Crowther R Anthony, Ghetti Bernardino, Spillantini Maria Grazia, Goedert Michel
Abstract excerpt
The identification of mutations in the Tau gene in frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) has made it possible to express human tau protein with pathogenic mutations in transgenic animals. Here we report on the production and characterization of a line of mice transgenic for the 383 aa isoform of human tau with the P301S mutation. At 5-6 months of age, homozygous animals from...
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