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Article

Neurodegeneration with tau accumulation in a transgenic mouse expressing V337M human tau.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Jan 2002

Tanemura Kentaro, Murayama Miyuki, Akagi Takumi, Hashikawa Tsutomu, Tominaga Takashi, Ichikawa Michinori, Yamaguchi Haruyasu, Takashima Akihiko

Abstract excerpt

Formation of neurofibrillary tangles (NFTs) is a common neuropathological feature found in several neurodegenerative diseases, including Alzheimer's disease. We have developed a transgenic (Tg) mouse expressing mutant human tau (V337M), derived from frontotemporal dementia parkinsonism-17. V337M Tg mice revealed tau aggregations in the hippocampus, which fulfills the histological criteria for NFTs in human...

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PMID: 11756496
PMCID: PMC6757582

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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