Cortical neuronal and glial pathology in TgTauP301L transgenic mice: neuronal degeneration, memory disturbance, and phenotypic variation.

doi:10.2353/ajpath.2006.051250

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Article

Cortical neuronal and glial pathology in TgTauP301L transgenic mice: neuronal degeneration, memory disturbance, and phenotypic variation.

The American journal of pathology - 1 Oct 2006

Murakami Tetsuro, Paitel Erwan, Kawarabayashi Takeshi, Ikeda Masaki, Chishti M Azhar, Janus Christopher, Matsubara Etsuro, Sasaki Atsushi, Kawarai Toshitaka, Phinney Amie L, Harigaya Yasuo, Horne Patrick, Egashira Nobuaki, Mishima Kenichi, Hanna Amanda, Yang Jing, Iwasaki Katsunori, Takahashi Mitsuo, Fujiwara Michihiro, Ishiguro Koichi, Bergeron Catherine, Carlson George A, Abe Koji, Westaway David, St George-Hyslop Peter, Shoji Mikio

Abstract excerpt

Recapitulation of tau pathologies in an animal model has been a long-standing goal in neurodegenerative disease research. We generated transgenic (TgTauP301L) mice expressing a frontotemporal dementia with parkinsonism linked to chromosome 17 (FTPD-17) mutation within the longest form of tau (2N, 4R). TgTauP301L mice developed florid pathology including neuronal pretangles, numerous Gallyas-Braak-positive...

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Identifiers

PMID: 17003492
DOI: 10.2353/ajpath.2006.051250
PMCID: PMC1698843

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