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Pathological phosphorylation of tau and TDP-43 by TTBK1 and TTBK2 drives neurodegeneration

6 Feb 2018

Abstract excerpt

BACKGROUND: Progressive neuron loss in the frontal and temporal lobes of the cerebral cortex typifies frontotemporal lobar degeneration (FTLD). FTLD sub types are classified on the basis of neuronal aggregated protein deposits, typically containing either aberrantly phosphorylated TDP-43 or tau. Our recent work demonstrated that tau tubulin kinases 1 and 2 (TTBK1/2) robustly phosphorylate TDP-43 and co-localize...

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PMID: 29409526
DOI: 10.1186/s13024-018-0237-9

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