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Article

TLR9 polymorphisms are associated with altered IFN-gamma levels in children with cerebral malaria.

The American journal of tropical medicine and hygiene - 1 Apr 2010

Sam-Agudu Nadia A, Greene Jennifer A, Opoka Robert O, Kazura James W, Boivin Michael J, Zimmerman Peter A, Riedesel Melissa A, Bergemann Tracy L, Schimmenti Lisa A, John Chandy C

Abstract excerpt

Toll-like receptor (TLR) polymorphisms have been associated with disease severity in malaria infection, but mechanisms for this association have not been characterized. The TLR2, 4, and 9 single nucleotide polymorphism (SNP) frequencies and serum interferon-gamma (IFN-gamma) and tumor necrosis factor-alpha (TNF-alpha) levels were assessed in Ugandan children with cerebral malaria (CM, N = 65) and uncomplicated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20348497
DOI: 10.4269/ajtmh.2010.09-0467
PMCID: PMC2844552

Genes

TLR9
TNF
TLR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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