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Article

Characterization of genetic variation and 3'-azido-3'-deoxythymidine- resistance mutations of human immunodeficiency virus by the RNase A mismatch cleavage method.

Proceedings of the National Academy of Sciences of the United States of America - 15 May 1991

López-Galíndez C, Rojas J M, Nájera R, Richman D D, Perucho M

Abstract excerpt

The RNase A mismatch cleavage method has been applied to the characterization of natural genetic variation of human immunodeficiency virus (HIV) from different geographical areas. The approach provides a rapid and simple assay for the analysis of differences in closely related viral isolates and allows the establishment of phylogenetic relationships between epidemiologically distinct viruses. Our results show a...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 2034672
DOI: 10.1073/pnas.88.10.4280
PMCID: PMC51642

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