Article
Zidovudine treatment results in the selection of human immunodeficiency virus type 1 variants whose genotypes confer increasing levels of drug resistance.
The Journal of general virology - 1 Feb 1994
Kellam P, Boucher C A, Tijnagel J M, Larder B A
Abstract excerpt
High level resistance to 3'-azido-3'-deoxythymidine (AZT, zidovudine or Retrovir) is conferred by the presence of four or five mutations (Met-41-->Leu; Asp-67-->Asn; Lys-70-->Arg; Thr-215-->Tyr or Phe; Lys-219-->Gln) in the human immunodeficiency virus (HIV) reverse transcriptase. The order of appearance of these five mutations in asymptomatic patients during therapy has been studied. This has enabled us to...
Topics
- Amino Acid Sequence
- Base Sequence
- Drug Resistance
- Genotype
- HIV Reverse Transcriptase
- HIV-1
- Humans
- Molecular Sequence Data
- Mutation
- RNA-Directed DNA Polymerase
- Recombination, Genetic