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Article

HIV-1 sensitivity to zidovudine: a consensus culture technique validated by genotypic analysis of the reverse transcriptase.

Journal of virological methods - 1 May 1992

Brun-Vézinet F, Ingrand D, Deforges L, Gochi K, Ferchal F, Schmitt M P, Jung M, Masquelier B, Aubert J, Buffet-Janvresse C

Abstract excerpt

In order to select and standardize a reliable assay for the analysis of sensitivity of HIV isolates to AZT, we have compared two culture methods. The first assay (Cell-Associated Isolate Sensitivity Assay: CAISA) quantified AZT-resistant HIV isolates by end-point dilution cultures of peripheral blood mononuclear cells (PBMCs) in the presence of various concentrations of AZT. In the second assay (Cell-Free Isolate...

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PMID: 1375948
DOI: 10.1016/0166-0934(92)90045-f

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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