Article
Dynamic changes in HIV-1 quasispecies from azidothymidine (AZT)-treated patients.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jul 1992
Wahlberg J, Albert J, Lundeberg J, Cox S, Wahren B, Uhlén M
Abstract excerpt
The emergence of azidothymidine (AZT)-resistant human immunodeficiency virus (HIV) variants in clinical samples was studied by a direct genomic sequencing method. Sequential lymphocyte samples from four patients, who had been treated with AZT for up to 27 months, were shown to gradually accumulat...
Topics
- Acquired Immunodeficiency Syndrome
- Amino Acid Sequence
- Drug Resistance, Microbial
- HIV-1
- Humans
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Sequence Homology, Nucleic Acid
- Time Factors
- Zidovudine