Article
In vivo comparison of zidovudine resistance mutations in blood and CSF of HIV-1-infected patients.
Neurology - 1 Dec 1993
Wildemann B, Haas J, Ehrhart K, Wagner H, Lynen N, Storch-Hagenlocher B
Abstract excerpt
Several mutations are associated with resistance to zidovudine (3'-azido-3'-deoxythymidine, AZT) in cultured human immunodeficiency virus type 1 (HIV-1) isolates. Little is known as to what extent drug resistance occurs in vivo and whether its development within the CNS differs from that in perip...
Topics
- Acquired Immunodeficiency Syndrome
- Base Sequence
- DNA, Viral
- Drug Resistance
- HIV Reverse Transcriptase
- HIV-1
- Humans
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- RNA-Directed DNA Polymerase
- Zidovudine