Article
Human immunodeficiency virus type 1 pol gene mutations in an AIDS patient treated with multiple antiretroviral drugs.
Journal of virology - 1 Dec 1993
Fitzgibbon J E, Farnham A E, Sperber S J, Kim H, Dubin D T
Abstract excerpt
Multiple mutations were found in the human immunodeficiency virus pol gene following treatment of an AIDS patient with antiretroviral drugs. After approximately 2.5 years of monthly alternating therapy with 3'-azido-3'-deoxythymidine (AZT) and 2',3'-dideoxycytidine (ddC), most of the pol sequence...
Topics
- Acquired Immunodeficiency Syndrome
- Amino Acid Sequence
- Base Sequence
- Consensus Sequence
- Didanosine
- Genes, pol
- Genotype
- HIV-1
- Humans
- Leukocytes, Mononuclear
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Mutation
- Point Mutation
- Polymerase Chain Reaction