Article
Reverse transcriptase mutations in sequential HIV-1 isolates in a patient with AIDS.
Journal of medical virology - 1 Jul 1995
Gurusinghe A D, Land S A, Birch C, McGavin C, Hooker D J, Tachedjian G, Doherty R, Deacon N J
Abstract excerpt
Sequential human immunodeficiency virus type 1 (HIV-1) isolates were obtained over a 29-month period from a person before, during, and after AZT therapy. DNA sequence analysis of polymerase chain-amplified reverse-transcriptase gene showed a gradual accumulation of mutations to peak resistance (I...
Topics
- Acquired Immunodeficiency Syndrome
- Adult
- Amino Acid Sequence
- Base Sequence
- Cells, Cultured
- DNA, Viral
- Drug Resistance, Microbial
- Female
- Follow-Up Studies
- Genes, Viral
- HIV Reverse Transcriptase
- HIV-1
- Humans
- Microbial Sensitivity Tests
- Molecular Sequence Data
- Mutation
- RNA-Directed DNA Polymerase
- Zidovudine