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Article

Use of self-sustained sequence replication amplification reaction to analyze and detect mutations in zidovudine-resistant human immunodeficiency virus.

The Journal of infectious diseases - 1 Dec 1991

Gingeras T R, Prodanovich P, Latimer T, Guatelli J C, Richman D D, Barringer K J

Abstract excerpt

Mutations at amino acid positions 67, 70, 215, and 219 in the human immunodeficiency virus type 1 (HIV-1) pol gene correlate with the emergence of resistance to zidovudine (AZT). These four positions were monitored in viral RNA extracted from infected peripheral blood mononuclear cells (PBMC) and viral stocks obtained after coculture with uninfected lymphocytes. Genotype determinations were made using the...

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PMID: 1955709
DOI: 10.1093/infdis/164.6.1066

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