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Article

BDNF val66met polymorphism, white matter abnormalities and remission of geriatric depression.

Journal of affective disorders - 1 Sept 2010

Alexopoulos George S, Glatt Charles E, Hoptman Matthew J, Kanellopoulos Dora, Murphy Christopher F, Kelly Robert E, Morimoto Sarah S, Lim Kelvin O, Gunning Faith M

Abstract excerpt

OBJECTIVE: The polymorphism BDNF val66met of the brain derived neurotrophic factor (BDNF) is common, may increase the risk for depression, and affects BDNF secretion, critical for neuronal survival, plasticity, neurogenesis, and synaptic connectivity. Our objectives were: 1) to test the hypothesis that BDNF(val/met) status influences the remission rate of geriatric depression; 2) to explore whether the...

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Identifiers

PMID: 20346518
DOI: 10.1016/j.jad.2010.02.115
PMCID: PMC2903650

Genes

BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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