Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Val66Met BDNF genotypes in melancholic depression: effects on brain structure and treatment outcome.

Depression and anxiety - 1 Mar 2013

Cardoner Narcís, Soria Virginia, Gratacòs Mònica, Hernández-Ribas Rosa, Pujol Jesús, López-Solà Marina, Deus Joan, Urretavizcaya Mikel, Estivill Xavier, Menchón José M, Soriano-Mas Carles

Abstract excerpt

BACKGROUND: A brain-derived neurotrophic factor (BDNF) prodomain single-nucleotide polymorphism resulting in a valine to methionine substitution (Val66Met) has been associated with depression-related phenotypes and brain alterations involving regions consistently associated with major depressive disorder (MDD). The aim of our study was to evaluate the association of regional gray matter (GM) volume within the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Substitution
Share to Brain-Derived Neurotrophic Factor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cerebral Cortex

Share to Depressive Disorder, Major

Share to Imaging, Three-Dimensional

Share to Magnetic Resonance Imaging

Share to Methionine

Share to Valine

Source

Identifiers

PMID: 23165919
DOI: 10.1002/da.22025

Genes

BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Val66Met BDNF genotypes in melancholic depression: effects on brain structure and treatment outcome.PMID 23165919Read ↗

Relationship between a BDNF gene polymorphism and the brain volume in treatment-naive patients with major depressive disorder: A VBM analysis of brain MRI.Semantic proximity Read ↗

Brain-derived neurotrophic factor Val66Met polymorphism affects cortical thickness of rostral anterior cingulate in patients with major depressive disorder.Semantic proximity Read ↗

Modulatory effects of brain-derived neurotrophic factor Val66Met polymorphism on prefrontal regions in major depressive disorder.Semantic proximity Read ↗

Hippocampal volumes and the brain-derived neurotrophic factor val66met polymorphism in geriatric major depression.Semantic proximity Read ↗

The effects of 5-HTTLPR and BDNF Val66Met polymorphisms on neurostructural changes in major depressive disorder.Semantic proximity Read ↗

Plasma BDNF Level in Major Depression: Biomarker of the Val66Met BDNF Polymorphism and of the Clinical Course in Met Carrier Patients.Semantic proximity Read ↗

The effect of depression, BDNF gene val66met polymorphism and gender on serum BDNF levels.Semantic proximity Read ↗

BDNF-related mutations in major depressive disorder: a systematic review.Semantic proximity Read ↗

Association of the brain-derived neurotrophic factor Val66Met polymorphism with reduced hippocampal volumes in major depression.Semantic proximity Read ↗

The BDNF gene Val66Met polymorphism as a modifier of psychiatric disorder susceptibility: progress and controversy.Semantic proximity Read ↗

BDNF Genetic Variant and Its Genotypic Fluctuation in Major Depressive Disorder.Semantic proximity Read ↗

Association study of a brain-derived neurotrophic-factor genetic polymorphism and major depressive disorders, symptomatology, and antidepressant response.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.