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Brain-derived neurotrophic factor Val66Met polymorphism and remission after antidepressant treatment in depressed Caucasian patients: a meta-analysis.

Psychiatry research - 1 Jun 2026

Cassam Sulliman Nora, Verstuyft Céline, Chappell Kenneth, Becquemont Laurent, Corruble Emmanuelle, Colle Romain

Abstract excerpt

INTRODUCTION: Major depressive disorder (MDD) is a leading global health concern. Personalized medicine could enable a better response to antidepressants. Findings suggested optimal response genotypes of Val66Met genetic polymorphism of brain-derived neurotrophic factor (BDNF) (rs6265) in Caucasian depressed patients: selective serotonin reuptake inhibitors (SSRIs) associated with better clinical improvement in...

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Antidepressive Agents
Brain-Derived Neurotrophic Factor
BDNF gene
Major Depressive Disorder

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

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PMID: 41812474
DOI: 10.1016/j.psychres.2026.117065

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BDNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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