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Article

MTR polymorphic variant A2756G and retinoblastoma risk in Brazilian children.

Pediatric blood & cancer - 1 Jul 2010

de Lima Elker Lene Santos, da Silva Vanessa Cavalcante, da Silva Hildson Dornelas Angelo, Bezerra Alexandre Medeiros, de Morais Vera Lucia Lins, de Morais Adriana Lins, Cruz Raquel Vera, Barros Mário Henrique Magalhães, Hassan Rocio, de Freitas Antonio Carlos, Muniz Maria Tereza Cartaxo

Abstract excerpt

BACKGROUND: Polymorphisms in the genes of folate and methionine metabolism enzymes have been associated with some forms of cancer by affecting DNA synthesis, repair, and methylation. PROCEDURE: A case-control study of 72 retinoblastoma cases and 98 cancer-free children controls was performed to investigate whether the polymorphisms of the methylenetetrahydrofolate reductase (MTHFR C677T and A1298C), methionine...

Read the complete abstract on PubMed

Topics

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Share to 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Infant, Newborn

Share to Methylenetetrahydrofolate Reductase (NADPH2)

Share to Reduced Folate Carrier Protein

Share to Retinal Neoplasms

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Share to Thymidylate Synthase

Source

Identifiers

PMID: 20310006
DOI: 10.1002/pbc.22472

Genes

MTR
MTHFR
TYMS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

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MTR polymorphic variant A2756G and retinoblastoma risk in Brazilian children.PMID 20310006Read ↗

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Association study of the common polymorphisms in the folate-methionine pathway with retinoblastoma.Semantic proximity Read ↗

Methionine synthase A2756G variation is associated with the risk of retinoblastoma in Iranian children.Semantic proximity Read ↗

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