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Article

Risk of retinoblastoma is associated with a maternal polymorphism in dihydrofolatereductase (DHFR) and prenatal folic acid intake.

Cancer - 1 Dec 2012

Orjuela Manuela A, Cabrera-Muñoz Lourdes, Paul Ligi, Ramirez-Ortiz Marco A, Liu Xinhua, Chen Jia, Mejia-Rodriguez Fabiola, Medina-Sanson Aurora, Diaz-Carreño Silvia, Suen Ida H, Selhub Jacob, Ponce-Castañeda M Veronica

Abstract excerpt

BACKGROUND: The incidence of unilateral retinoblastoma varies globally, suggesting possible environmental contributors to disease incidence. Maternal intake of naturally occurring folate from vegetables during pregnancy is associated inversely with the risk of retinoblastoma in offspring. METHODS...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22648968
DOI: 10.1002/cncr.27621
PMCID: PMC3434235

Genes

DHFR
MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22648968-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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