Article
Polymorphisms of methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTR), methionine synthase reductase (MTRR), and thymidylate synthase (TYMS) in multiple myeloma risk.
Leukemia research - 1 Mar 2008
Lima Carmen S P, Ortega Manoela M, Ozelo Margareth C, Araujo Renato C, De Souza Cármino A, Lorand-Metze Irene, Annichino-Bizzacchi Joyce M, Costa Fernando F
Abstract excerpt
We tested whether the polymorphisms of the methylenetetrahydrofolate reductase gene, MTHFR C677T and A1298C, the methionine synthase gene, MTR A2756G, the methionine synthase reductase gene, MTRR A66G, and the thymidylate synthase gene, TYMS 2R-->3R, involved in folate and methionine metabolism, altered the risk for multiple myeloma (MM). Genomic DNA from 123MM patients and 188 controls was analysed by polymerase...
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