Article
Impact of alterations affecting the p53 pathway in bladder cancer on clinical outcome, assessed by conventional and array-based methods.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jan 2002
Lu Ming-Lan, Wikman Friedrik, Orntoft Torben F, Charytonowicz Elizabeth, Rabbani Farhang, Zhang Zuofeng, Dalbagni Guido, Pohar Kamal S, Yu Guopei, Cordon-Cardo Carlos
Abstract excerpt
This study was designed to define the potential clinical relevance of identifying alterations affecting p53 pathway in bladder cancer and to test a new, low-cost, high-throughput, and array-based TP53 sequencing technology. Tumor samples from 140 evaluable patients with bladder cancer were analyzed with two methods to detect TP53 gene mutations, including single-stranded conformational polymorphism followed by...
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