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Article

DNase I hypersensitivity and epsilon-globin transcriptional enhancement are separable in locus control region (LCR) HS1 mutant human beta-globin YAC transgenic mice.

The Journal of biological chemistry - 7 May 2010

Shimotsuma Motoshi, Okamura Eiichi, Matsuzaki Hitomi, Fukamizu Akiyoshi, Tanimoto Keiji

Abstract excerpt

Expression of the five beta-like globin genes (epsilon, Ggamma, Agamma, delta, beta) in the human beta-globin locus depends on enhancement by the locus control region, which consists of five DNase I hypersensitive sites (5'HS1 through 5'HS5). We report here a novel enhancer activity in 5'HS1 that appears to be potent in transfected K562 cells. Deletion analyses identified a core activating element that bound to...

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Identifiers

PMID: 20231293
DOI: 10.1074/jbc.M110.116525
PMCID: PMC2863201

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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DNase I hypersensitivity and epsilon-globin transcriptional enhancement are separable in locus control region (LCR) HS1 mutant human beta-globin YAC transgenic mice.PMID 20231293Read ↗

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Hypersensitive site 2 specifies a unique function within the human beta-globin locus control region to stimulate globin gene transcription.Semantic proximity Read ↗

Context-dependent EKLF responsiveness defines the developmental specificity of the human epsilon-globin gene in erythroid cells of YAC transgenic mice.Semantic proximity Read ↗

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