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Article

Hypersensitive site 2 specifies a unique function within the human beta-globin locus control region to stimulate globin gene transcription.

Molecular and cellular biology - 1 Apr 1999

Bungert J, Tanimoto K, Patel S, Liu Q, Fear M, Engel J D

Abstract excerpt

The human beta-globin locus control region (LCR) harbors both strong chromatin opening and enhancer activity when assayed in transgenic mice. To understand the contribution of individual DNase I hypersensitive sites (HS) to the function of the human beta-globin LCR, we have mutated the core elements within the context of a yeast artificial chromosome (YAC) carrying the entire locus and then analyzed the effect of...

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Share to Chromosomes, Artificial, Yeast
Share to Deoxyribonuclease I

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Enhancer Elements, Genetic

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Share to Locus Control Region

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Source

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Identifiers

PMID: 10082573
DOI: 10.1128/MCB.19.4.3062
PMCID: PMC84100

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Hypersensitive site 2 specifies a unique function within the human beta-globin locus control region to stimulate globin gene transcription.PMID 10082573Read ↗

Deletion of the core region of 5' HS2 of the mouse beta-globin locus control region reveals a distinct effect in comparison with human beta-globin transgenes.Semantic proximity Read ↗

Synergistic and additive properties of the beta-globin locus control region (LCR) revealed by 5'HS3 deletion mutations: implication for LCR chromatin architecture.Semantic proximity Read ↗

Synergistic regulation of human beta-globin gene switching by locus control region elements HS3 and HS4.Semantic proximity Read ↗

The minimal requirements for activity in transgenic mice of hypersensitive site 3 of the beta globin locus control region.Semantic proximity Read ↗

Reconstitution of Human β-Globin Locus Control Region Hypersensitive Sites in the Absence of Chromatin AssemblySemantic proximity Read ↗

DNase I hypersensitivity and epsilon-globin transcriptional enhancement are separable in locus control region (LCR) HS1 mutant human beta-globin YAC transgenic mice.Semantic proximity Read ↗

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Position independence and proper developmental control of gamma-globin gene expression require both a 5' locus control region and a downstream sequence element.Semantic proximity Read ↗

The human β‐globin locus control regionSemantic proximity Read ↗

Heterozygosity for deletion of hypersensitive site 3 in the human locus control region has an unexpected minor effect on red cell phenotype.Semantic proximity Read ↗

The polyoma virus enhancer cannot substitute for DNase I core hypersensitive sites 2-4 in the human beta-globin LCR.Semantic proximity Read ↗

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