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Article

Deletion of the core region of 5' HS2 of the mouse beta-globin locus control region reveals a distinct effect in comparison with human beta-globin transgenes.

Blood - 15 Jan 2006

Hu Xiao, Bulger Michael, Bender M A, Fields Jennifer, Groudine Mark, Fiering Steven

Abstract excerpt

The beta-globin locus control region (LCR) is a large DNA element that is required for high-level expression of beta-like globin genes from the endogenous mouse locus or in transgenic mice carrying the human beta-globin locus. The LCR encompasses 6 DNaseI hypersensitive sites (HSs) that bind transcription factors. These HSs each contain a core of a few hundred base pairs (bp) that has most of the functional...

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Identifiers

PMID: 16189270
DOI: 10.1182/blood-2005-06-2308
PMCID: PMC1895626

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Deletion of the core region of 5' HS2 of the mouse beta-globin locus control region reveals a distinct effect in comparison with human beta-globin transgenes.PMID 16189270Read ↗

Hypersensitive site 2 specifies a unique function within the human beta-globin locus control region to stimulate globin gene transcription.Semantic proximity Read ↗

Synergistic and additive properties of the beta-globin locus control region (LCR) revealed by 5'HS3 deletion mutations: implication for LCR chromatin architecture.Semantic proximity Read ↗

Reconstitution of Human β-Globin Locus Control Region Hypersensitive Sites in the Absence of Chromatin AssemblySemantic proximity Read ↗

The minimal requirements for activity in transgenic mice of hypersensitive site 3 of the beta globin locus control region.Semantic proximity Read ↗

The mouse beta-globin locus control region: hypersensitive sites 3 and 4.Semantic proximity Read ↗

Human β-Globin Locus Control Region HS5Contains CTCF- and Developmental Stage-Dependent Enhancer-BlockingActivity in ErythroidCellsSemantic proximity Read ↗

The beta-globin LCR is not necessary for an open chromatin structure or developmentally regulated transcription of the native mouse beta-globin locus.Semantic proximity Read ↗

DNase I hypersensitivity and epsilon-globin transcriptional enhancement are separable in locus control region (LCR) HS1 mutant human beta-globin YAC transgenic mice.Semantic proximity Read ↗

Conserved elements containing NF-E2 and tandem GATA binding sites are required for erythroid-specific chromatin structure reorganization within the human beta-globin locus control region.Semantic proximity Read ↗

Cloning and functional characterization of LCR-F1: a bZIP transcription factor that activates erythroid-specific, human globin gene expression.Semantic proximity Read ↗

Definition of transcriptional promoters in the human beta globin locus control region.Semantic proximity Read ↗

Heterozygosity for deletion of hypersensitive site 3 in the human locus control region has an unexpected minor effect on red cell phenotype.Semantic proximity Read ↗

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