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Article

The role of transcriptional activator GATA-1 at human beta-globin HS2.

Nucleic acids research - 1 Aug 2008

Cho Youngran, Song Sang-Hyun, Lee Jong Joo, Choi Narae, Kim Chul Geun, Dean Ann, Kim AeRi

Abstract excerpt

GATA-1 is an erythroid activator that binds beta-globin gene promoters and DNase I hypersensitive sites (HSs) of the beta-globin locus control region (LCR). We investigated the direct role of GATA-1 interaction at the LCR HS2 enhancer by mutating its binding sites within minichromosomes in erythroid cells. Loss of GATA-1 in HS2 did not compromise interaction of NF-E2, a second activator that binds to HS2, nor was...

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Identifiers

PMID: 18586828
DOI: 10.1093/nar/gkn368
PMCID: PMC2504316

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The role of transcriptional activator GATA-1 at human beta-globin HS2.PMID 18586828Read ↗

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DNase I hypersensitivity and epsilon-globin transcriptional enhancement are separable in locus control region (LCR) HS1 mutant human beta-globin YAC transgenic mice.Semantic proximity Read ↗

Direct interaction of NF-E2 with hypersensitive site 2 of the β-globin locus control region in living cellsSemantic proximity Read ↗

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Conserved elements containing NF-E2 and tandem GATA binding sites are required for erythroid-specific chromatin structure reorganization within the human beta-globin locus control region.Semantic proximity Read ↗

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