Article
Synergistic regulation of human beta-globin gene switching by locus control region elements HS3 and HS4.
Genes & development - 15 Dec 1995
Bungert J, Davé U, Lim K C, Lieuw K H, Shavit J A, Liu Q, Engel J D
Abstract excerpt
Proper tissue- and developmental stage-specific transcriptional control over the five genes of the human beta-globin locus is elicited in part by the locus control region (LCR), but the molecular mechanisms that dictate this determined pattern of gene expression during human development are still...
Topics
- Animals
- Base Sequence
- Chromosomes, Artificial, Yeast
- Gene Expression Regulation, Developmental
- Globins
- Humans
- Mice
- Mice, Transgenic
- Molecular Sequence Data
- Mutation
- Oligodeoxyribonucleotides
- Polymerase Chain Reaction
- RNA, Messenger
- Transcriptional Activation