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Article

Synergistic regulation of human beta-globin gene switching by locus control region elements HS3 and HS4.

Genes & development - 15 Dec 1995

Bungert J, Davé U, Lim K C, Lieuw K H, Shavit J A, Liu Q, Engel J D

Abstract excerpt

Proper tissue- and developmental stage-specific transcriptional control over the five genes of the human beta-globin locus is elicited in part by the locus control region (LCR), but the molecular mechanisms that dictate this determined pattern of gene expression during human development are still controversial. By use of homologous recombination in yeast to generate mutations in the LCR within a yeast artificial...

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PMID: 8543153
DOI: 10.1101/gad.9.24.3083

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Synergistic regulation of human beta-globin gene switching by locus control region elements HS3 and HS4.PMID 8543153Read ↗

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